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Artichoke Extract

Save 49% Now - Artichoke Extract 450Mg  90 Vcaps
Now - Artichoke Extract 450Mg 90 Vcaps

Save 48% Solaray - Artichoke Leaves 405mg - 100ct Cap
Solaray - Artichoke Leaves 405mg - 100ct Cap

Save 45% Natures Way - Artichoke 60cap
Natures Way - Artichoke 60cap

Artichoke Extract

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The artichoke (Cynara scolymus)

The artichoke (Cynara scolymus) is not only a delicious nutritious food, it is also a valuable medicine. Its historical and folk use as a digestive aid and liver remedy is validated by detailed scientific investigations including double-blind clinical studies. The modern use of artichoke as a medicine utilizes extracts of the leaves of the plant standardized for key components known as caffelyquinic acids.

How does artichoke extract work?
Artichoke's basic mechanism of action centers around its affect on the liver. First, artichoke extract has been shown to enhance detoxification reactions as well as protect the liver from damage. This combination of benefits is very important to healthy liver function. During detoxification of the liver, the toxic substance is often initially converted to an even more toxic form. Without adequate protection, every time the liver neutralizes a toxin, it is damaged in this process. Artichoke extract has been shown to provide this valuable protection. Once the liver has modified a toxin, it needs to be eliminated from the body as soon as possible. One of the primary routes of elimination is through the bile. However, when the manufacture of bile is reduced or the excretion of bile is inhibited (a condition called cholestasis), toxins stay in the liver and body longer. Another rbeneficial effect of artichoke is that it acts as a choleretic.

Can artichoke extract really help improve digestion?
Absolutely. The evidence is provided by the results of a study evaluating a standardized artichoke extract in 553 patients with various digestive disorders. The average patient age in the study was 54.7 years. The average duration of use was 43.5 days. The most prominent diagnoses were dyspeptic discomforts (gas, bloating, intestinal cramping), gallbladder attacks, and severe constipation. The associated digestive disturbances had been present on average for 155 weeks prior to inclusin in the study. The standardized artichoke preparation was typically taken at a dosage of one to two of the 320mg capsules three times daily.

The digestive disturbances regressed after six weeks of treatment on average of 70.5%; the most pronounced regression was found for vomiting (88.3%), nausea (82.4%), abdominal pain (76.2%), loss of appetite (72.3%), constipation (71.0%), flatulence (68.2%), and fat intolerance (58.8%). In 85% of patients, the therapeutic efficacy of artichoke extract was judged by the physicians as excellent or good, in 12% as moderate, and in 3% as insufficient or minimal.

In another study of patients suffering from abdominal pain, bloating, constipation, lack of appetite, and nausea, artichoke extract produced improvements in 65% to 72% of patients after one week and 80% to 92% after six weeks.

Can artichoke extract help with irritable bowel syndrome (IBS)?
Irritable bowel syndrome is a disorder of the large intestine characterized by some combination of: (1) abdominal pain, (2) altered bowel function, constipation or diarrhea, (3) hypersecretion of colonic mucus, (4) dyspeptic symptoms (flatulence, nausea, anorexia), and (5) varying degrees of anxiety or depression. IBS has been referred to in the past as nervous indigestion, spastic colitis, mucous colitis, and intestinal neurosis.

Artichoke extract can help with IBS, but I would recommend giving enteric coated peppermint oil a try first. Several double-blind studies have shown enteric coated peppermint oil capsules to be a very effective treatment for IBS. Interic coating involves coating the capsule in a manner that will not allow the capsule to break down until after it has passed through the stomach and into the small intestine. Enteric coating is necessary, as menthol (the major constituent of peppermint oil) and other volatile compounds in peppermint oil would cause relaxation of the sphincter separating the esophagus and the stomach. Without enteric coating, a significant amount of heartburn would be produced.

These results are quite impressive. Enteric coated peppermint oil is thought to woek by improving the rhythmic contractions of the intestinal tract and relieving intestinal spasm. An additional benefit of peppermint oil is its effectiveness against Candida albicans. This action is important in IBS as an overgrowth of C. albicans may be an underlying factor, especially in cases that do not respond to dietary advice and for those who consume large amounts of sugar.

If you have IBS, I would recommend giving artichoke a try only if the enteric coated peppermint oil does not provide relief after a one month trial.

What about lowering Cholesterol?
Artichoke extract exerts a dual effect on cholesterol metabolism. First, it decreases the manufacture of cholesterol in the liver. Approximately 80% to 90% of cholesterol in the blood is manufactured by the liver and is not derived from the diet. The other way in which artichoke extract affects cholesterol levels is by increasing the conversion of cholesterol to bile acids. One of the functions of cholesterol is to be the building block of bile acids. I think in many people, one to the reasons that their cholesterol levels are high, is because of impaired conversion of cholesterol to bile acids. In this scenario, I believe the low bile acid levels result in sending a powerful signal to the liver to provide more cholesterol.

In the study evaluating artichoke extract in 553 patients with various digestive disorders, it improved digestion and significantly lowered blood cholesterol levels. In spite of the relatively short duration of therapy (six weeks on average), the study showed an 11.5% reduction in the average serum cholesterol from an initial average of 264 mg/dl to 188.07 mg/dl, corresponding to a decreased of 12.5%.

What is the proper dosage for artichoke extract? First of all, it's important to choose an artichoke product that is standardized to provide 13% to 18% caffeylquinic acids calculated as chlorogenic acid. The dosage for such a preparation is 160mg to 320 mg three times daily with meals.

Is artichoke extract safe? Absolutely! It is a food based extract. In a large safety study only one out of 100 subjects reported mild side effects (e.g., transient increase in flatulence).

*These statement have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

DescriptionSuggested Retail PriceOur Price SKU
Enzymatic Therapy - Artichoke Extract - 45 tabs $27.50 $15.07Save 45% ENZ-08809
Integrative Therapeutics - Artichoke Extract 45 tabs $27.50 $27.50 ITI-00225
Megafood - Daily Purify Nutrient Booster Powder - 2.1oz $19.96 $15.97Save 20% 51494-60139
Metagenics - Lipo-Gen - 90 Tablets $22.95 $22.95 MTG-LIPO
Natures Herbs - Artichoke Extract - 60 $17.89 $10.38Save 42% 41954-99645
Natures Herbs - Artichoke Power - 60 caps $17.89 $8.96Save 50% NH-01121
Natures Way - Artichoke 60cap $11.49 $6.30Save 45% NWAY-64600
Now - Artichoke Extract 450Mg 90 Vcaps $16.99 $8.73Save 49% NW-4592
Solaray - Artichoke Leaves 405mg - 100ct Cap $14.39 $7.49Save 48% SLRY-125

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