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Western herbal practitioners have prescribed lobelia for a wide variety of ailments including: allergies, asthma, arthritis, bronchitis, colds, coughs, croup, emphysema, epilepsy, fever, insomnia, lung disease, migraine headaches, mumps, pleurisy, pneumonia, toothaches, whooping cough and worms.

Because it has the ability to induce vomiting, it has been the subject of some controversy.

In the past, lobelia was approved for the use by the FDA as a deterrent to smoking in cases of nicotine withdrawal. Lobelia is considered an effective expectorant based on its ability to stimulate the adrenal glands to release corticosteroids that promote the relaxation of bronchial muscles.

Lobelia should be taken in exact prescribed dosages. Overdosing on lobelia can cause serious side effects.