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Physiologics - D 3   2000 IU     100 tabs Physiologics - D 3 2000 IU 100 tabs

SKU: PHY-17621    UPC: 716963176217

Suggested Retail Price: $15.99  SRP
 
Our Price: $14.39    Save 10%
  (Total Health web price as of 08/01/14)

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  • Supports calcium absorption from intestines to promote bone density and integrity*
  • Natural support for healthy cell growth and health of the immune system, colon, breast, and prostate*
  • High potency for older adults and residents of northern regions, whose bodies absorb and synthesize less vitamin D*
PRODUCT DISCUSSION
Vitamin D is best known for helping promote bone mass by increasing calcium absorption from the intestines and maintain calcium levels in the blood. Subjects who do not get adequate Vitamin D every day may not adequately absorb calcium from the foods in their diet, leading the body to take calcium from bones.

Vitamin D supplementation is a topic of great interest within the medical and scientific communities because of its role in promoting healthy cellular growth and function.* Food sources of Vitamin D are limited and include egg yolks, liver, and fatty fish; milk is fortified with Vitamin D. The body can produce Vitamin D when the skin is exposed to sunlight. Residents of northern regions, older adults, and people who use sunscreen may produce less Vitamin D and may consider supplementing with high-potency supplements to ensure adequate D status.* A clinical review concluded that daily supplementation with 1000 IU of Vitamin D could have a major positive impact on public health (Garland 2006).

A growing body of evidence suggests that Vitamin D helps promote healthy cellular growth in the breast, prostate, colon and other organs.* Vitamin D also may assist the immune system by helping to regulate T- and B-lymphocytes, supporting the ability of macrophages to defend the body, and promoting the synthesis of mononuclear cells*

STRUCTURE AND FUNCTION
The body synthesizes the active form of Vitamin D, 1,25-dihydroxyvitamin D3, from its two provitamin forms upon exposure to sunlight. The provitamins become active in the body after they are hydroxylated first in the liver and then in the kidney. The active form of Vitamin D has metabolic effects on cells and tissues.

Scientific research reveals interesting relationships between Vitamin D status and the health of several organ systems.* Numerous studies have found a positive association between colon health and Vitamin D, Vitamin D metabolites, sunlight exposure, or other markers of Vitamin D status.* Others have linked Vitamin D markers or sunlight with breast health.* Prostate health also appears to be positively correlated with Vitamin D status.*

Genetic polymorphisms, as found within the Vitamin D receptor, can affect Vitamin D status and in turn affect overall health. The bb genotype is associated with lower levels of plasma Vitamin D concentrations, and this same genotype also appears to affect colon, breast, and prostate health. Although the genotype we are born with cannot be altered, Vitamin D intake can be increased to maximize potential circulating levels of D metabolites.

In residents of northern climates, exposure to UV light may be inadequate to synthesize all of the Vitamin D required by the body. This becomes even more of a problem in winter months when there is less available sunlight and because people will have less skin exposed due to cold temperatures. The obvious solution is to increase Vitamin D intake from foods and supplements. Older individuals may especially benefit from higher levels of Vitamin D supplementation since it has been reported that Vitamin D absorption from the gastrointestinal tract decreases as a function of age. Dark-skinned individuals also synthesize relatively less Vitamin D from sun exposure, and are therefore excellent candidates for Vitamin D supplementation.

CLINICAL EVIDENCE
  • The results of five studies examining the association between serum vitamin D status and colon health were analyzed. A significant benefit to colon health was observed with the highest serum levels of 25(OH)D. Optimal serum levels were accomplished with daily doses of 1000 to 2000 IU/day of vitamin D3. This study supports the benefit of vitamin D supplementation to colon health. The recommendation of the authors to increase vitamin D intake to 1000-2000 mg/day corresponds to the dosage in our product. (Gorham et al, 2007)
  • A double-blind placebo controlled study was conducted to assess the association between vitamin D supplementation and musculoskeletal function in nursing home residents. 124 elderly subjects were randomized to receive daily doses of 200 IU, 400 IU, 600 IU, or 800 IU of vitamin D or placebo. Subjects receiving 800 IU/day of vitamin D experienced a significant benefit to their musculoskeletal function compared to placebo while those receiving lower doses did not experience a significant benefit. This study supports the use of higher dose of vitamin D to support muscle function and bone health. (Broe et al, 2007)
SUMMARY
Mounting clinical evidence suggests that Vitamin D can have a major impact on not only bones but also prostate, breast, ovary and colon cell health.* Variations in Vitamin D in the diet, exposure to sunlight, environmental conditions, gastrointestinal absorption, and genetic polymorphisms suggest that most adults should supplement with Vitamin D to ensure adequate intake and plasma concentrations.

SUGGESTED DOSAGE
For adults, take one (1) softgel or tablet daily, preferably with a meal, or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.

REFERENCES
Banwell, CM. Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells. Clin Cancer Res. 2006;12:2004-13.

Bao, BY, Ting HJ, Hsu JW, Lee YF. Protective role of 1alpha, 25dihydroxyvitamin D(3) against oxidative stress in nonmalignant human prostate epithelial cells. Int J Cancer. 2008 Mar 17; [Epub ahead of print]

Bao, BY, Yao J, Lee YF. 1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis. Carcinogenesis. 2006;27:1883-93. Epub 2006 Apr 19.

Beer, TM. Effect of calcitriol on prostate-specific antigen in vitro and in humans. Clin Cancer Res. 2006;12:2812-6.

Broe KE, Chen TC, Weinberg J, et al. A higher dose of vitamin D reduces the risk of falls in nursing home residents: A randomized, multiple-dose study. J Am Geriatr Soc. 2007;55:234-9.

Chaimuangraj, S. Lack of association of VDR polymorphisms with Thai prostate cancer as compared with benign prostate hyperplasia and controls. Asian Pac J Cancer Prev. 2006;7:136-9.

Cross HS. Nutritional regulation of extrarenal vitamin D hydroxylase expression - potential application in tumor prevention and therapy. Future Oncol. 2005;1:415-24.

Garland, C et al. The role of vitamin D in cancer prevention. Am J Publ Health. 2006; 96:9-18.

Gorham ED, Garland CF, Garland FC, et al. Optimal vitamin D status for colorectal cancer prevention. A quantitative meta analysis. Am Journal Prevent Med. 2007;32:210-6.

Grant, WB. Epidemiology of disease risks in relation to vitamin D insufficiency. Prog Biophys Mol Biol. 2006;92:65-79. Epub 2006 Feb 28.

Heaney, R. et al. Human serum 25-hydroxycholecacliferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003; 77:204-210.

Huth, PJ. Major scientific advances with dairy foods in nutrition and health. J Dairy Sci. 2006; 89:1207-21.

Kemmis, CM

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.


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