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Physiologics - Acetyl L-Carnitine 1000 mg 30 caps Physiologics - Acetyl L-Carnitine 1000 mg 30 caps

SKU: PHY-55236    UPC: 716963552363

Suggested Retail Price: $33.30  SRP
 
Our Price: $29.97    Save 10%
  (Total Health web price as of 10/01/14)

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  • Promotes nervous system health*
PRODUCT DISCUSSION
PhysioLogics Acetyl-L-Carnitine (ALCAR) is similar in form to the amino acid L-Carnitine. It is synthesized in the brain, liver, and kidneys by the enzyme carnitine acetyltransferase and plays a role in the metabolism of food into energy.* The acetyl group of Acetyl-L-Carnitine contributes to the production of the neurotransmitter acetylcholine, which is required for cognitive function.*

STRUCTURE AND FUNCTION
Structurally similar to the neurotransmitter acetylcholine, ALCAR serves as the precursor to acetyl coenzyme A. Animal studies have shown that ALCAR can support neurons in the hippocampus and prefrontal cortex, facilitating learning and memory functioning. Additionally, ALCAR promotes healthy levels of normal shingomyelin accumulation to promote membrane fluidity and stability.*

ALCAR also plays a key role in cellular energy metabolism, transporting long-chain fatty acids across the mitochondrial membranes where they are utilized for ATP production, and shuttling small-chain and medium-chain fatty acids out of the mitochondria in order to maintain healthy coenzyme A levels. ALCAR helps maintain complex I and complex IV activity of the electron transport chain in aged mitochondria to further facilitate the mitochondrial energy supply.*

Finally, ALCAR may have antioxidant tendencies, supporting cells against peroxidation and promoting levels of reduced Glutathione and Coenzyme Q10. This property prevents lipid, protein, and DNA oxidative damage, which may further support brain function.*

CLINICAL EVIDENCE
  • Thirty subjects completed a 3-month double-blind trial in which they received 1,000 mg of acetyl l-carnitine twice per day or an alternative preparation. At the end of the trial, the results demonstrated significant benefits in energy maintenance levels in those receiving acetyl lcarnitine compared to the alternative preparation. (Tomassini et al, 2004)
  • Twenty subjects participated in a 4-week observational study in which they received 1,000 mg of acetyl l-carnitine twice per day. By week 3, a significant improvement in nervous system function was observed compared with baseline, based on questionnaire results. (Osio et al, 2006)
SUMMARY
PhysioLogics Acetyl-L-Carnitine helps promote cognitive function, memory, and nervous system health, and supports mitochondrial energy production.*

SUGGESTED DOSAGE
For adults, take one (1) 1000 mg capsule up to two times daily, preferably with a meal, or follow the advice of a health care professional.

REFERENCES
Arrigo A, Casale R, Buonocore M, Ciano C. Effects of acetyl- L-carnitine on reaction times in patients with cerebrovascular insufficiency. Int. J Clin Pharm Res. 1990;10:133-7.

Barnes CA, Markowska AL, Ingram DK, et al. Acetyl-1-carnitine. 2: Effects on learning and memory performance of aged rats in simple and complex mazes. Neurobiol Aging. 1990;11:499-506.

Calvani M, Carta A, Caruso G, et al. Action of acetyl-L-carnitine in neurodegeneration and Alzheimer's disease. Ann N Y Acad Sci. 1992;663:483-5.

Carta A, Calvani M. Acetyl-L-carnitine: a drug able to slow the progress of Azheimer's disease? Ann N Y Acad Sci. 1991;640:228-32.

Carta A, Calvani M, Bravi D, Bhuachalla SN. Acetyl-L-carnitine and Alzheimer's disease: pharmacological considerations beyond the cholinergic sphere. Ann N Y Acad Sci. 1993;695:324-6.

Feher J, Papale A, Mannino G, et al. Mitotropic compounds for the treatment of age-related macular degeneration. Ophthalmologica. 2003;217:351-7.

Osio M, Muscia F, Zampini L, et al. Acetyl l-carnitine in the treatment of painful antiretroviral toxic neuropathy in human immunodeficiency virus patients: an open label study. J Peripher Nerv Syst. 2006;11:72-6.

Parnetti L, Abate G, Bartorelli L, et al. Multicentre study of lalpha-glyceryl-phosphorylcholine vs ST200 among patients with probable senile dementia of Alzheimer's type. Drugs Aging. 1993;3:159-64.

Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-Lcarnitine treatment in Alzheimer's disease. Neuro. 1991;41:1726-32.

Thal LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neuro. 1996;47:705-11.

Tomassini V, Pozzilli C, Onesti E, et al. Comparison of the effects of acetyl l-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomized, double-blind, crossover trial. J Neurol Sci. 2004;218:103-8.

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.


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