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Physiologics - CoQ-10 50 mg and L-Carnitine 250 mg  60 sgels Physiologics - CoQ-10 50 mg and L-Carnitine 250 mg 60 sgels

SKU: PHY-55214    UPC: 716963552141

Suggested Retail Price: $41.75  SRP
 
Our Price: $37.58    Save 10%
  (Total Health web price as of 04/19/14)

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PRODUCT IS A SYNERGISTIC MIXTURE OF
Coenzyme Q-10, L-Carnitine (as L-Carnitine Fumarate), Gamma Tocopherol, Vitamin E (as d-Alpha Tocopherol), Vitamin C (as Ascorbyl Palmitate)

PRODUCT DISCUSSION
Physiologics' Coenzyme Q-10 & L-Carnitine softgels provide two powerful ingredients to support heart health. CoQ-10 is an essential component of the mitochondrial electron transport chain, vital for the production of adenosine triphosphate (ATP) required for virtually every cellular process. By supporting the normal physiology of the heart, CoQ-10 promotes healthy circulation through myocardial tissue. L-Carnitine plays a role in fatty acid metabolism and supports muscle tissue. Together, these ingredients provide natural support for cardiovascular health.*

STRUCTURE AND FUNCTION
Coenzyme Q-10 is naturally found in the inner mitochondrial membrane of every cell in the human body and plays a fundamental role in the production of ATP. In the mitochondrial respiratory chain, CoQ-10 is the electron acceptor for mitochondrial complex I and complex II, and donates electrons to complex III during oxidative phosphorylation. Each pair of electrons in the electron transport chain must interact with CoQ-10, the rate-limiting component of the mitochondrial respiratory cycle.*

CoQ-10 is also a component of extra-mitochondrial redox chains, whose function is to remove excess reducing power formed during glycolysis when mitochondrial respiration is decreased. In its reduced form, CoQ-10 is a lipid-soluble antioxidant that readily provides electrons to neutralize superoxide and lipid radicals. Mitochondria are involved in the production of reactive oxygen species, and CoQ-10 scavenges these species to support the cell from oxidative stress that can lead to cell and DNA damage and premature aging.*

In addition, CoQ-10 has membrane stabilizing properties thought to be involved in the phospholipids-protein interaction that aids in the metabolism of prostaglandins. Myocardial calcium-dependent ion channels are stabilized by CoQ-10, which prevents depletion of molecules essential for ATP synthesis. CoQ-10 supports healthy blood flow to cardiac muscle.*

L-Carnitine is synthesized in the liver and kidneys from lysine and methionine, two essential amino acids. Of primary importance is L-Carnitine's obligate role in mitochondrial fatty acid metabolism and energy production. L-Carnitine shuttles long-chain fatty acids across the inner mitochondrial membrane in liver, heart, and skeletal muscle where they are oxidized for the release of free energy. The heart in particular is reliant on L-Carnitine for the production of energy from fat.*

INDICATIONS
CoQ-10 is a normal component of the mitochondrial electron transport chain and supports a healthy cardiovascular system. Endogenous levels of CoQ-10 may diminish with age, strenuous exercise, and environmental stressors. In addition, certain regularly prescribed drugs may cause CoQ-10 depletions. L-Carnitine is a conditionally essential nutrient important for the heart. Supplementing your clients' diets with Coenzyme Q-10 & L-Carnitine may be an opportunity to receive a daily supply of these important molecules for heart health.*

HOW CLIENTS MAY BENEFIT
  • Increase myocardial CoQ-10 levels for cardiovascular health support.*
  • Support cellular levels of ATP, the energy source for all biological processes.*
  • CoQ-10 is a powerful antioxidant that fortifies cells from the harmful effects of free radicals.*
  • Maintain oxidative phosphorylation for exercise support.*
  • L-Carnitine promotes fatty acid metabolism for cellular energy production.*

CLINICAL EVIDENCE
  • In one double-blind trial, Tran et al. administered daily doses of 100 mg of CoQ-10 to 80 patients for 17 weeks. Eighty-nine percent experienced support of cardiovascular function, respiratory function and muscle strength support. These benefits lasted during the entire course of treatment.
  • In a long-term study, Langsjoen et al. treated 424 patients with CoQ-10 in addition to their normal health regimes and monitored their heart health for eight years. Fifty-eight percent experienced promotion by one New York Heart Association (NYHA) class, 28% by two classes, and 1.2% by three classes.
  • In one double blind trial investigating the role of a modified form of Carnitine called propionyl-L-Carnitine (PC) in heart health, 500 mg PC daily was found to promote exercise tolerance by 26% after six months.
SUMMARY
Coenzyme Q-10 plays an essential role in the production of cellular ATP and cardiovascular health maintenance. Its role as an antioxidant supports tissue from oxidative damage. L-Carnitine transports fatty acids into mitochondria to promote cellular energy production. Supplementing your clients' nutritional regimes with PhysioLogics' Coenzyme Q-10 & L-Carnitine will support their cellular energy levels, to promote cardiovascular health.*

SUGGESTED DOSAGE
For adults, take one (1) softgel two to four times daily, preferably with meals, or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.

REFERENCES
Brass, E.P. Supplemental carnitine and exercise. Am J Clin Nutr. 2000. 71(suppl): 618S-623S.

Carter, A.L., et al. Biosynthesis and metabolism of carnitine. J Child. Neurol. 10(Suppl 2):S3-S7, 1995.

Center, S.A., et al. The clinical and metabolic effects of rapid weight loss in obese pet cats and the influence of supplemental oral L-carnitine. J Vet Intern Med. 2000. 14(6); Nov-Dec: 598-608.

Folkers K. Relevance of the biosynthesis of coenzyme Q-10 and the four bases of DNA as a rationale for the molecular causes of cancer and a therapy. Biochem Biophys Res Commun 1996;224:358-61.

Frei B, Kim MC, Ames BN.Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci U S A. 1990 Jun;87(12):4879-83.

Greenberg S, Frishman WH. Co-enzyme Q-10: a new drug for cardiovascular disease. J Clin Pharmacol. 1990 Jul;30(7):596-608

Kato T, Yoneda S, Kako T, Koketsu M, Hayano I, Fujinami T. Reduction in blood viscosity by treatment with coenzyme Q-10 in patients with ischemic heart disease. Int J Clin Pharmacol Ther Toxicol. 1990 Mar;28(3):123-6.

Langsjoen H, Langsjoen P, Langsjoen P, Willis R, Folkers K. Usefulness of coenzyme Q-10 in clinical cardiology: a long-term study. Mol Aspects Med. 1994;15 Suppl:s165-75.

Mancini M, Rengo F, Lingetti M, Sorrentino GP, Nolfe G. Controlled study on the therapeutic efficacy of propionyl-Lcarnitine in patients with congestive heart failure. Arzneimittelforschung. 1992 Sep;42(9):1101-4.

Mellors A, Tappel AL.The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem. 1966 Oct 10;241(19):4353-6

Mortensen SA, Vadhanavikit S, Muratsu K, Folkers K. Coenzyme Q-10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure. Int J Tissue React. 1990;12(3):155-62.

Nohl H, Gille L, Staniek K.The biochemical, pathophysiological, and medical aspects of ubiquinone function. Ann N Y Acad Sci. 1998 Nov 20;854:394-409.

Overvad K, Diamant B, Holm L, Holmer G, Mortensen SA, S

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.


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