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Physiologics - CoQ-10 Q-Sorb 120 mg 60 sgels Physiologics - CoQ-10 Q-Sorb 120 mg 60 sgels

SKU: PHY-01857    UPC: 716963018579

Suggested Retail Price: $52.00  SRP
 
Our Price: $46.80    Save 10%
  (Total Health web price as of 11/24/14)

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  • Supports cells and mitochondrial DNA from the harmful effects of reactive oxygen species*
PRODUCT DISCUSSION
PhysioLogics Coenzyme Q-10 Q-Sorb™ 120 mg provides an essential component of the mitochondrial electron transport chain, vital for the production of adenosine triphosphate (ATP) required for virtually all cellular processes. Co Q-10 is a lipophilic antioxidant that neutralizes the formation of reactive oxygen species in the mitochondria, which is important for cardiovascular health.*

Endogenous levels of Co Q-10 may diminish with age, strenuous exercise, and environmental stressors. In addition, certain regularly prescribed drugs, including statins, may deplete the body's supply of Co Q-10. (Note: Coenzyme Q-10 is not intended to serve as a replacement for statin therapy, nor should patients discontinue taking any prescribed medications while supplementing with Coenzyme Q-10.)

STRUCTURE AND FUNCTION
Coenzyme Q-10 is a vitamin-like molecule naturally found in the inner mitochondrial membrane of every cell in the human body. In the mitochondrial respiratory chain, Co Q-10 is the electron acceptor for mitochondrial complex I and complex II, and donates electrons to complex III during oxidative phosphorylation. Each pair of electrons in the electron transport chain must interact with Co Q-10, the rate-limiting component of the mitochondrial respiratory cycle.

Co Q-10 is also a component of extra-mitochondrial redox chains, whose function is to remove excess reducing power formed during glycolysis when mitochondrial respiration is decreased. In its reduced form, Co Q-10 is a lipid-soluble antioxidant that readily provides electrons to neutralize superoxide and lipid radicals. Mitochondria are the primary sources of intracellular reactive oxygen species (ROS), which are capable of mitochondrial DNA damage. Co Q-10 scavenges these species to support the cell and DNA and fight oxidative stress, neutralizing both the initiation and propagation of lipid peroxidation.

By supporting the normal physiological function of the heart, Co Q-10 promotes healthy circulation through myocardial tissue. Co Q-10 also has membrane stabilizing properties thought to be involved in the phospholipid-protein interaction that aids in the metabolism of prostaglandins. Myocardial calcium-dependent ion channels are stabilized by Co Q-10, which supports molecules essential for ATP synthesis. In addition, Co Q-10 seems to play a role in supporting the fluidity of membranes, important for physiological functions of receptors, carriers and membrane-bound enzymes.

CLINICAL EVIDENCE
In a double-blind, placebo-controlled, randomized study, subjects consuming Co Q-10 showed significant improvement in a 6-minute walk test, in breathing parameters, New York Heart Association (NYHA) classification, and fatigue. The administration of Co Q-10 to subjects led to a significant improvement in functional status, and quality of life. Coenzyme Q-10 was shown to effectively support overall well being including heart health. (Berman et al, 2004) In another randomized, double-blind, controlled trial, the effects of oral treatment with Co Q-10 (120 mg/day) were compared over one year in 144 subjects. Co Q-10 significantly increased the level of vitamin E in the blood, supported healthy HDL levels, and reduced molecules that cause oxidative stress. There was a significantly lower effect in the control group. (Singh et al, 2003)

SUMMARY
Coenzyme Q-10 plays an essential role in the production of cellular ATP.* Its role as an antioxidant supports cardiovascular tissue from oxidative damage.* Supplementing a patient's nutritional regimen with PhysioLogics Coenzyme Q-10 Q-Sorb™ 120 mg softgels will help support cellular energy production and also help promote cardiovascular health.*

SUGGESTED DOSAGE
For adults, take one (1) softgel daily, preferably with a meal, or follow the advice of a health care professional.

REFERENCES
Berman M, et al. Coenzyme Q10 in patients with endstage heart failure awaiting cardiac transplantation: A randomized, placebo-controlled study. Clin Cardiol. 2004;27:295-9.

Ebadi M, et al. Ubiquinone (coenzyme Q-10) and mitochondria in oxidative stress of Parkinson's disease. Bio Signals Recept. 2001;10:224-53.

Ernster, L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta. 1995;1271:195-204.

Greenberg S, Frishman WH. Co-enzyme Q-10: a new drug for cardiovascular disease. J Clin Pharmacol. 1990;30:596-608.

Kato T, et al. Reduction in blood viscosity by treatment with coenzyme Q-10 in patients with ischemic heart disease. Int J Clin Pharmacol Ther Toxicol. 1990;28:123-6.

Langsjoen PH, Langsjoen AM. The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human publications. Biofactors. 2003;18:101-11.

Mellors A, Tappel AL. The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem. 1966;241:4353-6.

Mortensen SA, et al. Coenzyme Q-10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure. Int J Tissue React. 1990;12:155-62.

Nair K, et al. Aging muscle. Am J Clin Nutr. 2005;81:953-63.

Nohl H, Gille L, Staniek K. The biochemical, pathophysiological, and medical aspects of ubiquinone function. Ann N Y Acad Sci. 1998;854:394-409.

Overvad K, et al. Coenzyme Q-10 in health and disease. Eur J Clin Nutr. 1999;53:764-70.

Rauchova H, Drahota Z, Lenaz G. Function of coenzyme Q in the cell: some biochemical and physiological properties. Physiol Res. 1995;44:209-16.

Ravikumar A, et al. Isoprenoid pathway and free radical generation and damage in neuropsychiatric disorders. Ind J Exp Biol. 2000;38:438-46.

Reis F, et al. Circadian and seasonal variation of endogenous ubiquinone plasma level. Chronobiol Int. 2002;19:599-614.

Singh RB, et al. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem. 2003;246:75-82.

Shults CW, et al. Coenzyme Q-10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann Neurol. 1997;42:261-4.

Tran MT, et al. Role of coenzyme Q-10 in chronic heart failure, angina, and hypertension. Pharmacotherapy. 2001;21:797-806.

Weber C, et al. Effect of dietary coenzyme Q-10 as an antioxidant in human plasma. Mol Aspects Med. 1994;15 Suppl:s97-102.

Wei YH, et al. Tandem duplications and large-scale deletions of mitochondrial DNA are early molecular events of human aging process. Ann N Y Acad Sci. 1996;786:82- 101.

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.


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