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Physiologics - EPA 408 mg/ DHA 288 mg (Omega-3 780 mg)  120 sgels Physiologics - EPA 408 mg/ DHA 288 mg (Omega-3 780 mg) 120 sgels

SKU: PHY-16087    UPC: 716963160872

Suggested Retail Price: $39.15  SRP
 
Our Price: $35.23    Save 10%
  (Total Health web price as of 11/27/14)

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BACKGROUND
Omega-3 fatty acids are considered to be "good" fats in the diet that may have numerous health benefits. The Omega-3 fatty acids Eicosapentanoic Acid (EPA) and Docosahexaenoic Acid (DHA) often are in short supply in the American diet because fatty fish are among the few food sources. Another Omega-3 fatty acid, Alpha-Linolenic Acid (ALA), is more abundant than EPA and DHA in the American diet. The body may be able to convert some ALA into EPA and DHA but the process is thought to be inefficient.

PRODUCT DISCUSSION
PhysioLogics EPA 408 mg/DHA 288 mg softgels deliver the long-chain polyunsaturated fatty acids EPA and DHA to support circulatory and neurological health.* Each 1.2 g softgel provides 34% EPA and 24% DHA, the highest concentration of EPA and DHA in the PhysioLogics line of products.

STRUCTURE AND FUNCTION
The family of Omega-3 fatty acids form part of the structure of membranes of every cell in the body and are essential for normal cell growth. EPA and DHA are direct precursors of a wide range of biologically important lipid mediators used in the support of virtually all biological functions, including those of the cardiovascular, reproductive, immune, and nervous systems.* Supportive but not conclusive research shows that consumption of EPA and DHA Omega-3 fatty acids may reduce the risk of coronary heart disease.

Each Omega-3 fatty acid has distinct functions. EPA supports a healthy vascular system.* It is beneficial for circulation and makes more efficient use of myocardial oxygen for heart health maintenance.* DHA is the most prevalent fatty acid of rod photoreceptor disc membranes in the eye and synaptic terminals in the brain, and is necessary for proper excitable membrane functions and fluidity.*

CLINICAL EVIDENCE
  • In a cross-sectional study conducted in 1,575 subjects, researchers found that higher consumption of linolenic acid was linked to lower prevalence of carotid plaques and decreased thickness of intimamedia carotid arteries. Thus, Omega-3 fatty acid consumption was positively associated with circulatory and overall heart health. (Djousse et al, 2003)
  • Researchers at the Harvard School of Public Health followed over 80,000 women and found that diets with a higher consumption of Omega-3 fatty acids were associated with heart health maintenance and quality of life. (Hu et al, 2002)
  • A study assessing the cognitive abilities of over 200 men and women aged 63-74 over a four year period showed higher level of Omega-3 fatty acids in erythrocyte membranes obtained from normal diet were associated with maintenance of cognitive function in the elderly. (Heude et al, 2003)
SUMMARY
Omega-3 polyunsaturated fatty acids are nutrients that may be lacking in most American diets. Supplementing with PhysioLogics EPA 408 mg/DHA 288 mg provides these important fatty acids that support their cardiovascular, nervous, and circulatory systems, as well as overall health.*

SUGGESTED DOSAGE
For adults, take one (1) softgel two times daily, preferably with a meal, or follow the advice of your health care professional.

REFERENCES
Albert CM, Campos H, Stampfer MJ, et al. Blood levels of long-chain w-3 fatty acids and the risk of sudden death. N Engl J Med. 2002;346:1113-8.

Bjerve K. w-3 fatty acid deficiency in man: Implications for the requirement of alpha-linolenic acid and long chain w- 3 fatty acids. World Rev Nutr Diet. 1991;66:133-42.

Carroll D, Roth M. Evidence for the cardioprotective effects of omega-3 fatty acids. Ann Pharmacother. 2002;36:1950-6.

DeLuca P, Rothman D, Zurier R. Marine and botanical lipids as immunomodulatory and therapeutic agents in the treatment of rheumatoid arthritis. Rheum Dis Clin N Am. 1995; 21:759-77.

Djousse L, et al. Dietary linolenic acid and carotid atherosclerosis. Am J Clin Nutr. 2003;77:819-25.

Heude B, Ducimetiere P, Berr C. Cognitive decline and fatty acid composition of erythrocyte membranes-The EVA study. Am J Clin Nutr. 2003;77:803-8.

Hu FB, et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA. 2002;287:1815-21.

Hu F, Cho E, Rexrode K, et al. Fish and long-chain w-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic women. Circulation. 2003;107:1852-7.

Sanders TA. Dietary fat and postprandial lipids. Curr Atheroscler Rep. 2003;5:445-51.

Simopoulos A. Symposium: Role of poultry products in enriching the human diet with N-3 PUFA. Human requirement for the N-3 polyunsaturated fatty acids. Poult Sci. 2000;79:961-70.

U.S. Department of Health and Human Services, Agency for Healthcare Research and Quality. Effects of Omega-3 Fatty Acids on Cardiovascular Disease Summary. Evidence Report/Technology Assessment: Number 94. http://www.ahrq.gov/clinic/epcsums/o3cardsum.htm

Youdim K, Martin A, Joseph J. Essential fatty acids and the brain: possible health implications. Int J Devl Neuroscience. 2000;18:383-99.

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.


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