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Physiologics - Joint Formula 120 sgels Physiologics - Joint Formula 120 sgels

SKU: PHY-07066    UPC: 716963070669

Suggested Retail Price: $47.25  SRP
 
Our Price: $42.52    Save 10%
  (Total Health web price as of 07/25/14)

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PRODUCT DISCUSSION
PhysioLogics Joint Formula utilizes Glucosamine and Chondroitin Sulfate, the same popular joint support ingredients backed by scientific research.* Glucosamine is an aminomonosaccharide which promotes the production of glycosaminoglycans (GAGs) and proteoglycans. Chondroitin promotes healthy enzymatic metabolism of cartilage. Citrus Bioflavonoids are water-soluble pigments. This formula combines key structural components in cartilage to support overall joint function, mobility and flexibility.*

STRUCTURE AND FUNCTION
Glucosamine, a key component of cartilage and synovial fluid, is an aminomonosaccharide utilized as the primary substrate in the synthesis of GAGs and proteoglycans. The amide group of Glucosamine is required for metabolic conversion into Glucosamine-6-phosphate, which is subsequently converted to galactosamine required for GAG assembly. Glucosamine from food and supplements is incorporated into the metabolic pathway of proteoglycan and GAG synthesis, promoting cartilage production and articular function.*

Chondroitin Sulfate is a natural constituent of cartilage, made up of repeating chains of GAGs. Chondroitin Sulfate is a highly charged polyanion, promoting water retention in the connective tissue to support joint flexibility and cushion joints.* Composed of N-acetyl-galactosamine and glucuronic acid, Chondroitin Sulfate provides a raw material for proteoglycan and GAG synthesis to actually help renew cartilage.* Chondroitin Sulfate also promotes healthy enzymatic metabolism of cartilage, to further maintain joint health.*

CLINICAL EVIDENCE
  • The Lancet published a double-blind placebo-controlled study that investigated the long-term effects of Glucosamine Sulfate in a trial of 212 subjects. After 3 years of taking 1500 mg/day of Glucosamine or placebo, the subjects who received Glucosamine maintained healthy joints, which was not observed in the placebo group. (Reginster et al, 2001)
  • In this study, 30 subjects receiving 1500 mg of Glucosamine per day were compared with 28 subjects receiving a placebo for 12 weeks. All participants had joint concerns at the beginning of the study. The subjects who received Glucosamine experienced a significant improvement in several aspects of joint comfort compared with placebo. (Usha et al, 2004)
  • A total of 120 subjects were given 800 mg Chondroitin Sulfate or placebo for two, three-month periods over the course of a year. Subjects receiving Chondroitin Sulfate had significantly improved knee function as compared to the placebo group. (Uebelhart et al, 2004)

 

SUMMARY
PhysioLogics Joint Formula supplies Glucosamine and Chondroitin, key structural components of cartilage that play important roles in the maintenance of joint cartilage.* 

SUGGESTED DOSAGE
For adults, take three (3) softgels daily, preferably one (1) softgel with each meal, or follow the advice of a health care professional.

REFERENCES
Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother. 1998;32:574-9.

Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage. 1998;6 Suppl A:31-6.

Clark CC, et al. Post-translational alterations in newly synthesized cartilage proteoglycans induced by the glutamine analogue 6-diazo-5-oxo-L-norleucine. Time course of inhibition and recovery. Biochem J. 1991;273(Pt 2):283-8.

da Camara CC, Dowless GV. Glucosamine sulfate for osteoarthritis. Ann Pharmacother. 1998;32:580-7.

Deal CL, Moskowitz RW. Nutraceuticals as therapeutic agents in osteoarthritis; the role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am. 1999;25:379-95.

Drovanti A, Bignamini AA, Rovati AL. Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: A placebo-controlled double-blind investigation. Clin Ther. 1980;3:260-72.

Lopes Vaz A. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthritis of the knee in outpatients. Current Med Res Opin. 1982;8:145-149.

Mazieres B, Combe B, Phan Van A, et al. Chondroitin sulfate in osteoarthritis of the knee: a prospective, double blind, placebo controlled multicenter clinical study. J Rheumatol. 2001;28:173-81.

Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001;357:251-6.

Uebelhart D, Malaise M, Marcolongo R, et al. Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. Osteoarthritis Cartilage. 2004;12:269-76.

Usha PR, Naidu MUR. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Investig. 2004;24;353-63.

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.


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