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Physiologics - L-Glutathione (Reduced) 250 mg   30 caps Physiologics - L-Glutathione (Reduced) 250 mg 30 caps

SKU: PHY-55215    UPC: 716963552158

Suggested Retail Price: $21.55  SRP
 
Our Price: $19.39    Save 10%
  (Total Health web price as of 08/20/14)

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PRODUCT DISCUSSION
Reduced glutathione is a powerful substance in the body that has regulatory and antioxidant roles. Scientific studies have shown that strenuous exercise may lead to increased imbalance between reactive oxygen species (ROS) and antioxidant defenses in the body.* PhysioLogics Reduced L-Glutathione acts as an antioxidant to help maintain oxidant homeostasis in the body.*

STRUCTURE AND FUNCTION
Glutathione is a peptide made up of three amino acids; glutamic acid, cysteine, and glycine. It is an important intracellular antioxidant that can protect cells, including muscle cells, from oxidative stress. Reduced glutathione donates an electron to reactive oxygen species and other free radicals. The oxidized product is then reduced again by glutathione reductase. Glutathione is also a co-factor for a powerful enzymatic antioxidant in the cells called glutathione peroxidase.

CLINICAL EVIDENCE
  • A study comparing 30 subjects with significantly elevated levels of reactive oxygen species (ROS) to a control group evaluated levels of reduced glutathione (GSH) and glutathione dependent enzymes. These subjects had significantly lower serum levels of reduced glutathione (p<0.05), and significantly higher levels of glutathione s-transferase (p<0.05) activity compared to controls. This was attributed to the use of gluthathione in reactions catalyzed by GST, such as those addressing free radicals and reactive oxygen species. The authors suggest an increased requirement for glutathione in times of oxidative stress, thus supporting glutathione's role as an antioxidant in the body. (Scibior et al, 2008)
  • In a lab test performed in Japan, human cells were exposed to oxidative stress. The addition of endogenous glutathione significantly neutralized the negative effects from oxidative stress on the cell (p<0.01). This study suggests a role for glutathione for the protection of the body's cells from oxidative stress. (Nakamura et al, 2008)
SUMMARY
PhysioLogics Reduced L-Glutathione 250 mg provides antioxidant support to the muscle cells during periods of strenuous exercise.*

SUGGESTED DOSAGE
For adults, take one (1) capsule two times daily, preferably with a meal, or follow the advice of a health care professional.

REFERENCES
Kelly FJ. Glutathione: in defence of the lung. Food Chem Toxicol. 1999;37:963-6.

Nakamura Y, Shimetani A, Fujii H, et al. Glutathione can efficiently prevent direct current-induced cytotoxicity. J Endod. 2008;24:693-7.

Powers SK, Ji LL, Leeuwenburgh C. Exercise traininginduced alterations in skeletal muscle antioxidant capacity: a brief review. Med Sci Sports Exerc. 1999; 31:987-97.

Scibior D, Skrzycki M, Podsiad M. Czeczot H. Glutathione level and glutathione-dependent enzyme activities in blood serum of patients with gastrointestinal tract tumors. Clin Biochem. 2008;41:852-8.

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.


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