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Physiologics - Melatonin 3 mg 120 vtabs Physiologics - Melatonin 3 mg 120 vtabs

SKU: PHY-07915    UPC: 716963079150

Suggested Retail Price: $11.35  SRP
 
Our Price: $10.21    Save 10%
  (Total Health web price as of 07/25/14)

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PRODUCT IS ALSO KNOWN AS:
n-Acetyl-5-Methoxytryptamine

PRODUCT DISCUSSION
Clinical trials involving orally supplemented melatonin have implicated this indoleamine to have positive metabolic interactions on various sleep parameters. Physiologic's supplies Melatonin at dosage levels consistent with published research which demonstrates its ability to promote calm, restful sleep.* This special formulation provides high-dosage melatonin for those who may need extra support for the pineal gland and other brain regions such as the suprachiasmatic nucleus and pars tuberalis.* Melatonin may also prove to be useful for frequent travelers experiencing jet lag.*

STRUCTURE AND FUNCTION
The pineal gland is the organ where information about light and dark is processed and then relayed to cells throughout the body. The eyes deliver information to the pineal gland through different routes that include the retinohypothalamic tract and the suprachiasmatic nuclei. Norepinephrine released from postganglionic nerve endings to the pineal gland helps control melatonin release. This release of norepinephrine to the pinealocytes occurs at night, which is when melatonin secretion and levels throughout the body begin to rise.*

Melatonin, due to its considerable lipophilicity, is able to cross any cell membrane and enter any tissue or cellular compartment. Therefore it is likely that some of melatonin's biochemical effects are elicited through intracellular binding sites in addition to its interactions with membrane-bound receptors (Hardeland, 95).

Melatonin's high lipophilicity is what allows it to transmit the signal of darkness to every cell in the body, in turn acting as the eyes for each cell, organ and tissue. This is why melatonin levels throughout the body are so important for promoting calm, restful sleep and a relaxed mood in the evening by supporting natural circadian rhythms.*

In addition to its effects on sleep, Melatonin is believed to play a major role in the biological termination of free radical induced redox reactions.* Melatonin is reported to have a large capacity to trap hydroxyl radicals, the free radical species with the highest relative reactivity. Melatonin also efficiently traps peroxyl radicals and superoxide anions. Melatonin participates in a two-step process in which it first interacts with a hydroxyl or peroxyl radial to give a melatonyl cation radical, which then combines with a superoxide anion to neutralize the electrical charges and pairing electrons.*

INDICATIONS
Occasional sleeplessness can affect anyone - young or old. The National Institutes of Health recommends keeping a regular schedule of going to bed and waking up at the same time every day, even on weekends, to help your body maintain a normal circadian rhythm. However, due to life's demands this is not realistic for many people. Endogenous melatonin is an important component of your body's circadian rhythm. Supplemental melatonin can provide circadian rhythm support for calm, restful sleep - especially when experiencing occasional sleeplessness or jet lag.* Clients who may not have responded to lower dose melatonin or to other alternatives make viable candidates for exogenous supplementation.*

HOW CLIENTS MAY BENEFIT*
  • Although many products and ingredients on the market are currently sold for promoting sleep and a relaxed mood in the evening, melatonin is the #1 product in terms of clinical testing for efficacy in a wide variety of populations.*
  • High dose of melatonin for those who may have not responded to lower doses or alternative preparations.*
  • Those who travel often and experience jet lag can benefit from the convenience of taking only one melatonin tablet to promote tranquil sleep.*
  • Participates in free-radical scavenging to support antioxidant action in the brain and across various cellular regions due to its high lipophilicity.*
  • Suitable for a wide-range of clients due to its free of status for yeast, wheat, milk or milk derivatives, lactose, sugar, preservatives, soy, sodium (less than 5mg per serving), and artificial color and flavor as certified through analysis of raw material specification sheets.
  • Finished product is suitable for vegetarians.

 

CLINICAL EVIDENCE
  • The clinical effects of melatonin on sleep latency and duration, mood, performance, oral temperature and changes in serum melatonin levels were examined in twenty male volunteers. Investigators employed a double blind, placebo controlled study utilizing repeated measures, within-subjects and a 5x5 Latin square design. Subjects received placebo or four different doses of melatonin on five different occasions. Statistical analysis revealed that all four melatonin doses had significant positive effects on sleep duration, self-reported sleepiness and fatigue, oral temperature and sleep-onset latency. The authors concluded that melatonin can be a highly potent hypnotic agent.
  • To measure the effects of exogenous melatonin on jet-lag due to rapid transmeridian translocation, 3mg of melatonin was given to elite athletes traveling across multiple time zones. Actograms were constructed from sleep log diaries by using the Circadia Data Analysis program and statistics were measured by nonparametric repeated-measures ANOVA. Positive correlations were found between preflight melatonin production rates (measuring 6-sulphatoxymelatonin).

 

SUMMARY
When it comes to supporting nocturnal sleep patterns, melatonin is the #1 supplement in terms of clinical trials and efficacy.* Melatonin's ability to interact with membrane-bound receptors as well as intracellular binding sites help translate the message of darkness and sleep to each cell in the body.* Just one tablet can be taken in the evening to help promote a relaxed mood and restful sleep.* Physiologics offers high-quality melatonin that is vegetarian-suitable, free of substantial allergenic materials and dosed at levels consistent with published, clinical research.*

SUGGESTED DOSAGE
For adults, take one (1) tablet, only at bedtime as Melatonin may produce drowsiness, or follow the advice of your health care professional. DO NOT EXCEED 3 MG IN A 24-HOUR PERIOD. As a reminder, discuss the supplements and medications you take with your health care providers.

 

 

REFERENCES
Cardinali, D.P., et al. A multifactorial approach employing melatonin to accelerate resynchronization of sleep - wake cycle after a 12 time-zone westerly transmeridian flight in elite soccer athletes. J Pineal Res. 2002. 32: 41-46.

Cavallo, A. et al. Blood pressure-lowering effect of melatonin in type 1 diabetes. J. Pineal Res. 2004.

Dollins A.B, et al. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature and performance. Proc Nat?l Acad Sci. 1994. 91; 1824-1828

Engstrom, J., et al. Evaluation and treatment of orthostatic hypotension. Amer Fam Phys. 1997. 56(5): 1-8.

Girouard, H., et al. Vasorelaxant effects of the chronic treatment with melatonin on mesenteric artery and aorta of spontaneously hypertensive rats. J Hypertens. 2001. 19(8): 1369-77

Hardeland, R., et al. Versatile Melatonin: a pervasive molecule serves various functions in signaling and protection. Chronobio Int?l.

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.


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