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Physiologics - MSM (Methylsulfonylmethane) 1000 mg 90 caps Physiologics - MSM (Methylsulfonylmethane) 1000 mg 90 caps

SKU: PHY-55125    UPC: 716963551250

Suggested Retail Price: $18.05  SRP
 
Our Price: $16.25    Save 10%
  (Total Health web price as of 08/20/14)

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  • Increases mobility and range of motion*
PRODUCT DISCUSSION
PhysioLogics MSM contains Methylsulfonylmethane (MSM), an organic source of sulfur, a mineral that is vital in the formation of collagen, connective tissue, and healthy joint cartilage.* It is one of the top three ingredients found in popular joint products.

STRUCTURE AND FUNCTION
Sulfur plays an important role in nutrition. It is the eighth most abundant element, and is an integral component of more than 150 compounds in the body. Sulfur is fundamental to the structure and integrity of certain tissues, including hair, skin, nails, and joints.* MSM is a dietary source of sulfur that is found widely in nature; major sources include milk, eggs, seafood, meats and plants.

MSM clinical trials have focused on cartilage and joint support.* Cartilage is a fibrous, elastic connective tissue that functions as a cushioning layer for joints and is comprised of an extracellular matrix made of complex proteins known as glycosaminoglycans (GAGs) and proteoglycans. Sulfur is used in the body as a constituent of certain amino acids, collagen and disulfide bonds, and provides a raw material for the production of GAGs and collagen.*

CLINICAL EVIDENCE
  • 118 subjects participated in a clinical trial in which they received 500 mg of MSM or placebo 3 times per day for 12 weeks. Those receiving MSM experienced a significant increase in joint comfort compared with the placebo group. Our product provides up to 3 grams of MSM per day. (Usha and Naidu, 2004)
  • 40 subjects completed a clinical trial in which they received 3 g of MSM or placebo twice per day for 12 weeks. Those receiving MSM experienced significant improvements in joint comfort and function compared with placebo. Our product provides up to 3 grams of MSM. (Kim et al. 2006)
SUMMARY
Sulfur is one of the building blocks of collagen and GAGs, key structural components in cartilage.* The compounds play an important role in the integrity and maintenance of joint cartilage.* MSM is a natural dietary source of sulfur which helps support the health of joints and cartilage.*

SUGGESTED DOSAGE
For adults, take one (1) capsule two to three times daily (1000 mg), preferably with meals, or follow the advice of a health care professional.

REFERENCES
Beilke MA, Collins-Lech C, Sohnle P. Effects of dimethyl sulfoxide on the oxidative function of human neutrophils. J Lab Clin Med. 1987;110:91-6.

Jacobs B. MSM packs a sulfuric punch. Nutr Sci Rev. 1999;4:232-4.

Kim LS et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis and Cartilage. 2006. 14(3):286-294.

Oae S, Okuyama T. Organic sulfur chemistry: biochemical aspects. Boca Raton, FL:CRC Press, 1992.

Parcell S. Sulfur in human nutrition and applications in medicine. Altern Med Rev. 2002;7:22-44.

Sharif M, Osborne DJ, Meadows K, et al. The relevance of chondroitin and keratan sulphate markers in normal and arthritic synovial fluid. Br J Rheumatol. 1996;35:951-7.

Usha PR and Naidu MUR. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug Investigation. 2004. 24(6):353-363.

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.


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