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Physiologics - NSK-SD Nattokinase 50 mg 100 sgels Physiologics - NSK-SD Nattokinase 50 mg 100 sgels

SKU: PHY-14466    UPC: 716963144667

Suggested Retail Price: $47.15  SRP
 
Our Price: $42.44    Save 10%
  (Total Health web price as of 04/17/14)

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HOW PATIENTS MAY BENEFIT
  • Supports heart and circulatory health*
  • Helps maintain healthy blood flow*

PRODUCT DISCUSSION
For more than a century, people throughout Asia have been consuming soybeans in a variety of food products. Scientists have isolated and patented a beneficial enzyme, named nattokinase, from soybean natto.

STRUCTURE AND FUNCTION
The vegetable cheese-like food, natto, is extremely popular in Japan and has a history extending back over 1,000 years. Nattokinase is a naturally occurring protease enzyme derived from soybean Natto. This enzyme is a subtilisin-like serine protease composed of 275 amino acid residues and has a molecular weight of 27.7 kDa. Nattokinase is present in the blood plasma and helps support the cardiovascular system. The potency of each nattokinase dose is standardized according to its Nattokinase activity as fibrinolytic units (FU). PhysioLogics NSK-SD™ Nattokinase contains 1,000 FU per softgel. This product helps support cardiovascular and circulatory health.*

CLINICAL EVIDENCE
  • In this trial, 73 subjects received either nattokinase containing 2,000 FU per capsule or placebo for eight weeks. The treatment group demonstrated a significantly greater improvement in heart health compared with placebo group. (Kim et al, 2008)
  • A total of 28 subjects received a daily oral dose of 250 mg of NKCP, a refined version of nattokinase, for two weeks. In a follow-up trial, 23 of the subjects received the same dose for twelve weeks. Significant fibrinolytic effect was demonstrated by an enhancement of euglobulin lysis time in both trials. Significant improvement in shoulder joint comfort was also observed. (Omura et al, 2004)

SUMMARY
Nattokinase is an enzyme isolated and extracted from fermented soybeans. While many forms of Nattokinase are available in the marketplace, Physiologics Nattokinase undergoes in-house testing to confirm 1,000 units of Fibrinolytic Activity per softgel. Testing methods correspond to the only approved methods of the Japan Nattokinase Research Association. PhysioLogics NSK- SD™ Nattokinase helps support heart and circulatory health.*

SUGGESTED DOSAGE
For adults, take one (1) softgel two times daily, preferably with a meal, or follow the advice of a health care professional.

NSK-SD™ is a registered trademark of Japan Bio Science Laboratories.

REFERENCES
Fujita M, et al. Characterization of nattokinase-degraded products from human fibrinogen or cross-linked fibrin. Fibrinolysis 1995;9:157.

Fujita M, Hong K, Ito Y, et al. Transport of nattokinase across the rat intestinal tract. Biol Pharm Bull. 1995;18:1194-6.

Fujita M, Nomura K, Hong K, et al. Purification and characterization of a strong fibrinolytic enzyme (nattokinase) in the vegetable cheese natto, a popular soybean fermented food in Japan. Biochem Biophys Res Commun. 1993;197:1340-7.

Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-91.

Iwai K, Nakaya N, Kawasaki Y, Matsue H. Inhibitory effect of natto, a kind of fermented soybeans, on LDL oxidation in vitro. J Agric Food Chem. 2002;50:3592-6.

Kim JY, et al. Effect of nattokinase on blood pressure: A randomized, controlled trial. Hypertension Research. 2008;31:1583-8.

Omura K, Hitosugi M, Kaketani K, et al. Fibrinolytic and antithrombotic effect of NKCP, the protein layer from Bacillus subtilis (natto). Biofactors. 2004;22:185-7.

Omura K, Hitosugi M, Zhu X, et al. A newly derived protein from Bacillus subtilis natto with both antithrombotic and fibrinolytic effects. J Pharmacol Sci. 2005;99:247-51. Epub 2005 Oct 27.

Sumi H, Hamada H, Tsushima H, et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987;43:1110-1.

Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-43.

Yamashita T, Oda E, Giddings JC, Yamamoto J. The effect of dietary bacillus natto productive protein on in vivo endogenous thrombolysis. Pathophysiol Haemost Thromb. 2003;33:138-43.

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.


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