Life Extension - Immune Senescence Protection Formula 60 Veg Caps
Standardized Cistanche, Reishi, Pu-erh Tea
This oral formula of Cistanche tubulosa extract and Reishi mushroom offers dual-mechanism immune support. Cistanche plant extract stimulates the development of naive T-cells for defending against new invaders. Reishi mushroom boosts the function of the innate immune cells, the immune system's first line defenders. Pu-erh tea is rich in polyphenols and other bioactive compounds to promote bone marrow health, which in turn supports healthy cellular immune function. Taken together, these natural extracts provide a robust, youthful immune response.
Benefits at a Glance
Dual-action formula restores a robust, youthful immune response
Cistanche and Reishi mushroom extracts help rejuvenate an aging immune system
Strengthen the immune systems response to new invaders
Restore a healthy immune cell helper-to-suppressor ratio
Rejuvenate the Aging Immune System
As we age, our once-vigorous immune system begins to decline, a process known as immune senescence.1 A vital immune system is composed of a healthy balance of naive T-cells that attack new invaders and memory T-cells that attack previously known invaders. However, after a naive T-cell attacks a new threat, it becomes a memory T-cell, which will only go after a threat that it remembers.2,3 The result is that the delicate immune balance tips and we have a surplus of memory T-cells and a deficit of naive T-cells. With this imbalance, our body is less able to defend itself against new invasions. This produces a less-vigilant immune system or immune senescence.4,5
Life Extension researchers have developed an innovative, dual-mechanism formula designed to combat immune senescence. Immune Senescence Protection Formula is composed of two botanical compounds that work in a complementary fashion to rejuvenate an aging immune system through unique mechanisms.
Cistanche Rejuvenates Aging Immune System
Scientists have discovered that the echinacoside compound found in the Cistanche plant extract stimulates the development of naive T-cells and leads to a lower number of memory T cells, thereby creating a more balanced immune response. Cistanche also increases natural killer (NK) cell activity resulting in a 15% life span increase in animal research.6
A 12-week human study of a dietary supplement containing standardized Cistanche resulted in impressive improvements in the immune profile after supplementation. Subjects had significant improvements, including an 11.7% increase in natural killer (NK) cell activity and a 20.2% improvement in the ratio of CD4 to CD8 cells. An increased CD4/CD8 ratio is indicative of healthy, youthful immune function.7
Reishi Mushroom Combats Immune Senescence
The numerous bioactive components of the Reishi mushroom exert powerful effects that may reverse many of the factors of immune senescence.6 Primarily, Reishi extracts boost the function of innate immune cells, the immune system's first line of defense.8-10
It has long been known that Reishi's unique polysaccharides, triterpenes, and other constituents11,12 enhance the body's hematopoietic stem cells, T-cells, and other crucial immune factors.13-15 Animal research shows Reishi supports multiple aspects of immune function and longevity.16
Pu-erh Tea Extract Supports Immune Balance
Immune Senescence Protection Formula now includes Pu-erh tea extractproviding additional and unique protection.
The cultivation of Pu-erh tea began over 2,000 years ago and was historically consumed by emperors to provide them with longevity. Pu-erh tea is rich in polyphenols and other bioactive molecules, including theabrownins, a unique group of compounds developed during the post-fermentation process.17
Modern science has shown that Pu-erh tea extract may support healthy bone marrow function, which helps to rebuild the peripheral immune cellular components.18 An animal study demonstrated that Pu-erh tea extract supports immune balance by decreasing interleukin-6 (IL-6) by a remarkable 43%, as well as increasing natural killer (NK) cells by 7% and nave T cells by 10%.18
Potent, Dual-Extract Formulation
Now, Cistanche, Reishi and Pu-erh Tea are all available in one powerful, dual-extract formulation, specifically created for year-round support of the aging immune system.
Serving Size 2 vegetarian tablets
Servings Per Container 30
Amount Per Serving
Calcium (as calcium carbonate)
Reishi mushroom extract (fruit body) [std. to 13.5% polysaccharides, 6% triterpenes]
Pu-erh tea extract (leaf) [providing polyphenols, theabrownin]
Cistanche tubulosa extract (stem and leaf) [std. to 22% echinacosides]
Shell-broken reishi mushroom (spore)
Other ingredients: microcrystalline cellulose, starch, croscarmellose sodium, stearic acid, aqueous film coating (hypromellose, glycerin, purified water), hydroxypropyl cellulose, maltodextrin, silica, vegetable stearate.
Dosage and Use
Take two (2) tablets daily with food, or as recommended by a healthcare practitioner.
Each serving contains approximately 32.5 mg of caffeine (the amount found in about a 3/4 cup brewed green tea).
KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
J Pathol 2007 Jan; 211(2): 144-156.
Immun Ageing. 2012 Jul 25;9(1):15.
Available at: http://www.nia.nih.gov/health/publication/biology-aging/immune-system-can-your-immune-system-still-defend-you-you-age Accessed May 21, 2015.
Immunity. 2008 Dec 19;29(6):848-62.
Curr Pharm Des. 2013;19(9):1680-98.
Evid Based Complement Alternat Med. 2014;2014:601383.
Anti-Aging Medicine. 2011;8(2):7-14.
Am J Chin Med. 2011;39(1):15-27.
Available at: http://www.merckmanuals.com/home/immune_disorders/biology_of_the_immune_system/ overview_of_the_immune_system.html. Accessed September 25, 2014.
Immunol Lett. 2002;83(3):163-9.
Am-Euras. J. Bot. 2008;1 (3): 107-11.
Bioorg Med Chem. 2010 Dec15;18(24):8583-91.
Front Pharmacol. 2012;3:135.
Int J Med Mushrooms. 2011;13(5):441-8.
FASEB J. 2011;25:601.2.
Food Research International. 2013;53(2):619-28.
Food Chem. 2012 Dec 15;135(4):2222-8.