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Physiologics - CoQ-10 Q-Sorb 120 mg w/Cinnamon 1000mg 30 sgels Physiologics - CoQ-10 Q-Sorb 120 mg w/Cinnamon 1000mg 30 sgels

SKU: PHY-55545    UPC: 716963555456

Suggested Retail Price: $30.80  SRP
 
Our Price: $27.72    Save 10%
  (Total Health web price as of 04/21/14)

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  • Supports antioxidant health*
  • Promotes sugar metabolism*
PRODUCT DISCUSSION
PhysioLogics Coenzyme Q-10 120 mg & Cinnamon 1000 mg provides an essential component of the mitochondrial electron transport chain, vital for the production of adenosine triphosphate (ATP) required for virtually all cellular processes. Co Q-10 is a lipophilic antioxidant that neutralizes the formation of reactive oxygen species in the mitochondria, which is important for cardiovascular health.*

Endogenous levels of Co Q-10 may diminish with age, strenuous exercise, and environmental stressors. In addition, certain regularly prescribed drugs, including statins, may deplete the body's supply of Co Q-10. (Note: Coenzyme Q-10 is not intended to serve as a replacement for statin therapy, nor should patients discontinue taking any prescribed medications while supplementing with Co Q-10.)

In a laboratory study, researchers tested approximately 50 different varieties of herbs and spices to measure their effects on sugar metabolism. It was found that Cinnamon was the most bioactive ingredient tested. The researchers concluded that Cinnamon's natural polyphenols and other components probably contributed to the beneficial effects. Taking advantage of the benefits of Cinnamon in supplement form may be a more practical choice than relying on the small amounts in foods.

STRUCTURE AND FUNCTION
Coenzyme Q-10 is a vitamin-like molecule naturally found in the inner mitochondrial membrane of every cell in the human body. In the mitochondrial respiratory chain, Co Q-10 is the electron acceptor for mitochondrial complex I and complex II, and donates electrons to complex III during oxidative phosphorylation. Each pair of electrons in the electron transport chain must interact with Co Q-10, the rate-limiting component of the mitochondrial respiratory cycle.

Co Q-10 is also a component of extra-mitochondrial redox chains, whose function is to remove excess reducing power formed during glycolysis when mitochondrial respiration is decreased. In its reduced form, Co Q-10 is a lipidsoluble antioxidant that readily provides electrons to neutralize superoxide and lipid radicals. Mitochondria are the primary sources of intracellular reactive oxygen species (ROS), which are capable of mitochondrial DNA damage. Co Q-10 scavenges these species to support the cell and DNA and fight oxidative stress, neutralizing both the initiation and propagation of lipid peroxidation.

By supporting the normal physiological function of the heart, Co Q-10 promotes healthy circulation through myocardial tissue.* Co Q-10 also has membrane stabilizing properties thought to be involved in the phospholipid-protein interaction that aids in the metabolism of prostaglandins. Myocardial calcium-dependent ion channels are stabilized by Co Q-10, which supports molecules essential for ATP synthesis. In addition, Co Q-10 seems to play a role in supporting the fluidity of membranes, important for physiological functions of receptors, carriers and membrane-bound enzymes.

Cinnamon is an ancient herb that has been used for thousands of years and has an expansive range of historical uses in many different cultures. It naturally contains the important compounds eugenol and cinnamaldehyde, and has been traditionally used for wellness. Cinnamon has been shown to enhance in vitro glucose uptake and glycogen synthesis and to increase phosphorylation of the insulin receptor. As a supplement, Cinnamon helps support sugar and fat metabolism in the body.*

CLINICAL EVIDENCE
  • In a double-blind, placebo-controlled, randomized study conducted by Berman et al, subjects consuming Co Q-10 showed significant improvement in a 6-minute walk test, breathing parameters, New York Heart Association (NYHA) classification, and fatigue.The administration of Co Q-10 to subjects led to a significant improvement in functional status and quality of life. Coenzyme Q-10 was shown to effectively support overall well being including heart health. (Berman et al, 2004)
  • A total of 34 subjects were evaluated for plasma coenzyme Q-10 levels during and after a trial of receiving 80 mg/day of a statin drug. Coenzyme Q-10 levels were measured at baseline, at 14 days into treatment, and at the end of the 30-day treatment period. Coenzyme Q-10 levels decreased significantly at days 14 and 30. The results of this study show that statins may deplete the body's supply of Coenzyme Q-10. (Rundek et al, 2004)
  • In a randomized placebo-controlled, clinical trial, 60 men and women were given 1, 3, or 6 g of cinnamon daily or matching placebo for 40 days. After 40 days, those in the cinnamon group had significantly improved scores in glucose, triglyceride, and cholesterol metabolic parameters. No changes were seen in the placebo group. This trial demonstrated that all three doses of cinnamon effectively supported sugar and fat metabolism. (Khan et al, 2003)
SUMMARY
Coenzyme Q-10 plays an essential role in the production of cellular ATP.* Its role as an antioxidant supports cardiovascular tissue from oxidative damage.* Cinnamon helps support sugar and fat metabolism.*

SUGGESTED DOSAGE
For adults, take one (1) softgel daily, preferably with a meal, or follow the advice of a health care professional.

REFERENCES
Anderson RA, Broadhurst CL, Polansky MM, et al. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem 2004;52:65-70.

Berman M et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: A randomized, placebocontrolled study. Clin Cardiol. 2004;27:295-9.

Broadhurst C, et al. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem. 2000;48:849-52.

Ebadi M, et al. Ubiquinone (coenzyme Q-10) and mitochondria in oxidative stress of Parkinson's disease. Bio Signals Recept. 2001;10:224-53.

Ernster, L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta. 1995;1271:195-204.

Greenberg S, Frishman WH. Co-enzyme Q-10: a new drug for cardiovascular disease. J Clin Pharmacol. 1990;30:596-608.

Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr. 2001;20:327-36.

Kato T, et al. Reduction in blood viscosity by treatment with coenzyme Q-10 in patients with ischemic heart disease. Int J Clin Pharmacol Ther Toxicol. 1990;28:123-6.

Khan A, Safdar M, Ali Khan MM, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003;6:3215-8.

Langsjoen PH, Langsjoen AM. The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human publications. Biofactors. 2003;18:101-11.

Mellors A, Tappel AL. The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem. 1966;241:4353-6.

Coenzyme Q-10 120 mg & Cinnamon 1000 mg CLINICAL EVIDENCE continued Mortensen SA, et al. Coenzyme Q-10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure. Int J Tissue React. 1990;12:155-62.

Nair K, et al. Aging muscle. Am J Clin Nutr. 2005;81:953-63.

Nohl H, Gille

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.

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