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Physiologics - Glucosamine Chondroitin HP  120 tabs Physiologics - Glucosamine Chondroitin HP 120 tabs

SKU: PHY-06656    UPC: 716963066563

Suggested Retail Price: $37.05  SRP
Our Price: $33.34    Save 10%
  (Web price as of 11/27/15...not applicable to in-store purchases)

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  • Helps promote healthy cartilage and joints*
  • Supports range of motion, mobility, cushioning, and flexibility for comfortable movement*


Physiologics Glucosamine/Chondroitin HP combines Glucosamine and Chondroitin Sulfate, two ingredients that have been studied together in clinical trials more than any other combination of joint ingredients. Glucosamine, an aminomonosaccharide, provides the building blocks for constructing cartilage.* Chondroitin promotes healthy enzymatic metabolism of cartilage.* Together, these ingredients support overall joint function, mobility, flexibility, total joint space and comfort.*

Glucosamine, a key component of cartilage and synovial fluid, is utilized as the main substrate in the synthesis of glycosaminoglycans (GAG)s and proteoglycans, the primary structural components in cartilage. Glucosamine undergoes metabolic conversion to glucosamine-6phosphate and subsequently to galactosamine, which is required for GAG assembly. This process promotes cartilage production and articular function.*

Chondroitin Sulfate is a highly charged polyanion that promotes fluid retention in the connective tissue to support joint flexibility and cushion joints.* Composed of N-acetyl-galactosamine and glucuronic acid, Chondroitin Sulfate provides a raw material for proteoglycan and GAG synthesis to help renew cartilage.* Chondroitin Sulfate also promotes healthy enzymatic metabolism of cartilage, to further maintain joint health.*

  • In this double-blind placebo/celecoxib-controlled trial, 1583 subjects received one of the following daily for 24 weeks: 1500 mg of glucosamine HCL, 1200 mg of chondroitin sulfate, both glucosamine HCL and chondroitin sulfate, 200 mg of celecoxib, or placebo. In the subgroup of subjects with the most joint concerns, those receiving the combination of glucosamine and chondroitin experienced a significant improvement in knee function compared to placebo. (Clegg et al, 2006)
  • In this study, 30 subjects receiving 1500 mg of glucosamine per day were compared with 28 subjects receiving a placebo for 12 weeks. All participants had joint concerns at the beginning of the study. The subjects who received the glucosamine experienced a significant improvement in several aspects of joint comfort compared with placebo. (Usha et al, 2004)


Both Glucosamine and Chondroitin are key structural components of cartilage and play important roles in the maintenance of joint cartilage.*

For adults, take three (3) tablets per day with food, or follow the advice of a health care professional.


Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother. 1998;32:574-9.

Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage. 1998;6 Suppl A:31-6.

Clark CC, Richards CF, Iozzo RV. Post-translational alterations in newly synthesized cartilage proteoglycans induced by the glutamine analogue 6-diazo-5-oxo-Lnorleucine. Time course of inhibition and recovery. Biochem J. 1991;273:283-8.

Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006;354:795-808.

D'Ambrosio E, Casa B, Bompani R, et al. Glucosamine sulphate: a controlled clinical investigation in arthrosis. Pharmatherapeutica. 1981;2:504-8.

De Camara CC, Dowless GV. Glucosamine sulfate for osteoarthritis. Ann Pharmacother. 1998;32:580-7.

Deal CL, Moskowitz RW. Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am. 1999;25:379-95.

Drovanti A, Bignamini AA, Rovati AL. Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: a placebocontrolled double-blind investigation. Clinical Therapeutics. 1980; 3:260-72.

Giordano N, Nardi P, Senesi M, et al. The efficacy and safety of glucosamine sulfate in the treatment of gonarthritis. Clin Ter. 1996; 147:99-105. Italian.

Lopes Vaz A. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthritis of the knee in outpatients. Current Med Res Opin. 1982;8:145-9.

Mazieres B, Combe B, Phan Van A, et al. Chondroitin sulfate in osteoarthritis of the knee: a prospective, double blind, placebo controlled multicenter clinical study. J Rheumatol. 2001;28:173-81.

Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001;357:251-6.

Usha PR, Naidu MUR. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Investig. 2004;24:353-63.

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.

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