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Physiologics - Melatonin 1 mg 90 vtabs Physiologics - Melatonin 1 mg 90 vtabs

SKU: PHY-55106    UPC: 716963551069

Suggested Retail Price: $8.75  SRP
 
Our Price: $7.88    Save 10%
  (Total Health web price as of 04/21/14)

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PRODUCT IS ALSO KNOWN AS:
n-Acetyl-5-Methoxytryptamine

PRODUCT DISCUSSION
Clinical trials involving orally supplemented melatonin have implicated this indoleamine to have positive metabolic interactions on various sleep parameters. Physiologic's supplies Melatonin at dosage levels consistent with published research which demonstrates its ability to promote calm, restful sleep. Melatonin may also prove to be useful for frequent travelers experiencing jet lag.*

STRUCTURE AND FUNCTION
The pineal gland is the organ where information about light and dark is processed and then relayed to cells throughout the body. The eyes deliver information to the pineal gland through different routes that include the retinohypothalamic tract and the suprachiasmatic nuclei. Norepinephrine released from postganglionic nerve endings to the pineal gland helps control melatonin release. This release of norepinephrine to the pinealocytes occurs at night, which is when melatonin secretion and levels throughout the body begin to rise.*

Melatonin, due to its considerable lipophilicity, is able to cross any cell membrane and enter any tissue or cellular compartment. Therefore it is likely that some of melatonin's biochemical effects are elicited through intracellular binding sites in addition to its interactions with membrane-bound receptors (Hardeland, 95). Melatonin's high lipophilicity is what allows it to transmit the signal of darkness to every cell in the body, in turn acting as the eyes for each cell, organ and tissue. This is why melatonin levels throughout the body are so important for promoting calm, restful sleep and a relaxed mood in the evening by supporting natural circadian rhythms.*

In addition to its effects on sleep, Melatonin is believed to play a major role in the biological termination of free-radical induced redox reactions. Melatonin is reported to have a large capacity to trap hydroxyl radicals, the free radical species with the highest relative reactivity. Melatonin also efficiently traps peroxyl radicals and superoxide anions. Melatonin participates in a two-step process in which it first interacts with a hydroxyl or peroxyl radial to give a melatonyl cation radical, which then combines with a superoxide anion to neutralize the electrical charges and pairing electrons.*

INDICATIONS
Occasional sleeplessness can affect anyone - young or old. The National Institutes of Health recommends to keep a regular schedule of going to bed and waking up at the same time every day, even on weekends, to help your body maintain a normal circadian rhythm. However, due to life's demands this is not realistic for many people. Endogenous melatonin is an important component of your body's circadian rhythm. Supplemental melatonin can provide circadian rhythm support for calm, restful sleep - especially when experiencing occasional sleeplessness or jet lag.*

HOW CLIENTS MAY BENEFIT
  • Although many products and ingredients on the market are currently sold for promoting sleep and a relaxed mood in the evening, melatonin is the #1 product in terms of clinical testing for efficacy in a wide variety of populations.
  • Those who travel often and experience jet lag can benefit from the convenience of taking only one melatonin tablet to promote tranquil sleep.
  • Participates in free-radical scavenging to support antioxidant action in the brain and across various cellular regions due to its high lipophilicity.
  • Suitable for a wide-range of clients due to its free of status for yeast, wheat, milk or milk derivatives, lactose, sugar, preservatives, soy, sodium (less than 5 mg per serving), and artificial color and flavor as certified through analysis of raw material specification sheets.
  • Finished product is suitable for vegetarians.

CLINICAL EVIDENCE
  • The clinical effects of melatonin on sleep latency and duration, mood, performance, oral temperature and changes in serum melatonin levels were examined in twenty male volunteers. Investigators employed a double blind, placebo controlled study utilizing repeated-measures, within-subjects and a 5x5 Latin square design. Subjects received placebo or .1, .3, 1 or 10mg of melatonin on five different occasions. Statistical analysis revealed 1mg of melatonin to be the most efficient dosage for the parameters studied. Subjects reported they slept more quickly after the 1mg dose as compared to the .1mg dose. Subjects also reported that they felt sleepier after the 1 and 10mg dosages as compared to placebo. 1mg also decreased oral temperature more then .1mg, which is a normal response to endogenously secreted melatonin as part of the circadian rhythm. Melatonin at 1mg was also effective for helping induce a relaxed mood and hypnotic-like state, which could support calm, restful sleep. (Dollins, 94)
  • In a double-blinded study, healthy volunteers were randomized to receive .3mg, 1mg or a placebo dose on three separate occasions. It was found that the 1mg dosage decreased sleep onset latency time and latency to stage 2 sleep - both positive findings. Sleep efficiency was also improved relative to placebo condition. The investigators attributed the positive findings to the acute action of melatonin on the physiological sleep process. (Zhdanova, 96)
SUMMARY
When it comes to supporting nocturnal sleep patterns, melatonin is the #1 supplement in terms of clinical trials and efficacy. Melatonin's ability to interact with membrane-bound receptors as well as intracellular binding sites help translate the message of darkness and sleep to each cell in the body. Just one tablet can be taken in the evening to help promote a relaxed mood and restful sleep. Physiologics offers high-quality melatonin that is vegetarian-suitable, free of substantial allergenic materials and dosed at levels consistent with published, clinical research.*

SUGGESTED DOSAGE
For adults, take one (1) tablet daily, at bedtime as Melatonin may produce drowsiness. Do not exceed recommended dose. As a reminder, discuss the supplements and medications you take with your health care providers.

REFERENCES
Cardinali, D.P., et al. A multifactorial approach employing melatonin to accelerate resynchronization of sleep - wake cycle after a 12 time-zone westerly transmeridian flight in elite soccer athletes. J Pineal Res. 2002. 32: 41-46.

Cavallo, A. et al. Blood pressure-lowering effect of melatonin in type 1 diabetes. J. Pineal Res. 2004.

Dollins A.B, et al. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature and performance. Proc Nat´l Acad Sci. 1994. 91; 1824-1828

Engstrom, J., et al. Evaluation and treatment of orthostatic hypotension. Amer Fam Phys. 1997. 56(5): 1-8.

Girouard, H., et al. Vasorelaxant effects of the chronic treatment with melatonin on mesenteric artery and aorta of spontaneously hypertensive rats. J Hypertens. 2001. 19(8): 1369-77

Hardeland, R., et al. Versatile Melatonin: a pervasive molecule serves various functions in signaling and protection. Chronobio Int´l. 1995. 12(3):157-165

Kemp, S. et al. The value of melatonin for sleep disorders occurring post-head injury: a pilot RCT. Brain Injury. 2004. 18(9).

Kitajima, T. The effects of oral melatonin on the autonomic function in healthy subj

The statements included above have not been evaluated by the FDA or Total Health. This product is not intended to diagnose, treat, cure or prevent any disease.


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